Sentence examples for bound with high specificity from inspiring English sources
A complementary DNA was isolated that encoded a protein, 3BP-1, to which the SH3 region of Abl bound with high specificity and to which SH3 regions from other proteins bound differentially.
Successful inhibitor design requires a region where small molecules or peptides can be bound with high specificity.
As shown in Figure 1B and Figure S1, in the presence of Mn2+, Fur dimers bound with high specificity and affinity to PhilD, with an apparent binding constant (KDapp) of about 4.5±1.5 nM, defined as the protein concentration necessary to complex 50% of labeled DNA.
We previously demonstrated that SC18 HA bound with high specificity and high affinity to human receptors, while AV18 HA bound with high affinity to avian receptors.
The chlorotoxin (CTx) is a scorpion-derived peptide, which binds with high specificity to glioma cell surface as a specific chloride channel and matrix metalloproteinase-2 blocker.
As cell signaling is a dynamic process, where proteins at low concentrations must often interact and dissociate rapidly and yet bind with high specificity, highly evolved protein-protein interactions are expected, to facilitate efficient recognition.
The HIF dimers present in nuclear extracts bind with high specificity to this response element and are subsequently detected with an antibody directed against Hif1 α.
As an angiogenesis-specific targeting ligand, we mainly used the cyclic RGD peptide, which binds with high specificity to the αvβ3 integrins expressed on angiogenic endothelium.
A trimeric complex (nuclear factors YA-C (Y-box binding factors)), forming a highly conserved, ubiquitously expressed transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes.
In a number of species, including man, anti-CENP-A antibodies bind with high specificity to the loci where centromeres are formed, either within the satellite DNA arrays which contain them or within the neocentromeres which substitute for them in a limited number of cases.
Aptamers are modified nucleotides composed of single-stranded nucleic acids that adopt a specific three-dimensional conformation, allowing them to bind with high specificity and affinity to molecular targets in a manner similar to that of monoclonal antibodies.
