In other tests, the researchers demonstrated that the versions of Dscam made by the insect bound with different affinities to the bacterium Escherichia coli, possibly indicating that variants are tuned to specific pathogens.
To investigate the role of the CD21/CD35 coreceptor in B cell competition for follicular retention and survival within the germinal center, either Cr2+ or Cr2null lysozyme-specific transgenic B cells were adoptively transferred into normal mice immunized with duck (DEL) or turkey (TEL) lysozyme, which bind with different affinities.
SP is a tachykinin which binds with different affinities to three neurokinin receptors (NKR 1 3), but mainly to NKR1, which is expressed in the central nervous system (CNS) and the skin [11].
Estrogens bind with different affinities to these different ER types [ 46, 47], which could provide diverse physiological outcomes in unique circumstances or stages of development.
Numerous tumour, epithelial or stromal-derived growth factors (GFs) bind with different affinities and specificities to the different ErbB family members.
Even though all type I IFNs use the same receptor it has been shown that they bind with different affinities and even induce different sets of interferon-stimulated genes (Lavoie et al., 2011).
These three compounds bind with different affinities to B-cell lymphoma 2 (Bcl-2), BCL2L1 long isoform (Bcl-xL) and BCL2L2 (Bcl-w) proteins and displace Bak, Bad and Bax.
In addition, OCRL1 isoforms were shown to bind with different affinity to clathrin.
Heparin is perhaps the most reliable, it is competitive with IP3, but it is membrane-impermeant, and its binding to the IBC of IP3Rs is influenced by more distant residues that cause it to bind with different affinity to each IP3R subtype.
Asymmetry in nucleotide binding and hydrolysis between each MutS ATPase site produces different nucleotide bound states with different affinities for hetero- and homo-duplex DNA [ 42].
