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We focus on the crystal structure (1kv2) bound with most potent MAPK inhibitor, BIRB796 (Figure 5A), and the crystal structure (1kv1) bound with a micomolar diaryl urea type of inhibitor (Figure 5B).
The results using the crystal structure bound with a micomolar diaryl urea type of inhibitor are similar, and high-ranking fragment hits mimic binding interactions seen for the picomolar inhibitor (Figure 5D).
Similar(58)
Miss Harkins is 18 and college bound with a scholarship.
— and bound with a white balsamic vinaigrette for some sass.
We just bound with a classical union bound: (19).
The man's hands were behind his back, the wrists bound with a cord.
For Brad, being "fluid bound" with a partner is the ultimate form of intimacy.
A broom bound with silk sweeps as well as one bound with string.
(A) Docking model of AXT bound with STAT3.
The Power Knee is a unique prosthetic with sensors and actuators, bound with artificial intelligence.
— bound with old cloth.
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