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Additionally, it was found that the G15V variant bound with a higher affinity to SmDia-RBD than the Q64L variant.
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In our previous studies the novel AMC compounds 11a, 12a and 12d bound with a high-affinity to the DA D2-high receptor and were full agonists compared to DA itself; DA, 11a and 12a were similarly potent, and 12d was a little more potent [19].
It binds with a higher affinity and has a longer intravitreal half-life than ranibizumab and bevacizumab.
Hsp90 inhibitors bind with a high affinity to the ATP-binding pocket and block the chaperone ATPase cycle leading to the degradation of client proteins (2, 3).
It binds with a high affinity to cell-surface lectins [ KD = 0.12 nM (33)] and was developed specifically for sentinel lymph node mapping.
In particular, the 3′ overhang, 5′ overhang, and 5′ flap were bound with a much higher affinity than the other substrates tested (Fig. 1D).
Fgfs also bind with a relatively high affinity to heparan sulphates, which in general are present as covalently linked side chains on cell-surface proteoglycans.
The YSX monobody bound with higher affinity, a slower off rate and a more favorable enthalpic contribution than the YS monobody.
The designed PNA probe (CJE195) bound with higher affinity to a previously reported low affinity site on the 16S rRNA than the corresponding DNA probe.
Third, as a general trend, synthetic oligo duplexes at the identified sites bind PhoP with a higher affinity for those having fewer mismatches (Table 2).
Following activation, T cells upregulate and translocate CTLA-4 receptor molecules to the surface, which bind B7 with a higher avidity than CD28.
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