In our previous studies the novel AMC compounds 11a, 12a and 12d bound with a high-affinity to the DA D2-high receptor and were full agonists compared to DA itself; DA, 11a and 12a were similarly potent, and 12d was a little more potent [19].
Additionally, it was found that the G15V variant bound with a higher affinity to SmDia-RBD than the Q64L variant.
Hsp90 inhibitors bind with a high affinity to the ATP-binding pocket and block the chaperone ATPase cycle leading to the degradation of client proteins (2, 3).
It binds with a high affinity to cell-surface lectins [ KD = 0.12 nM (33)] and was developed specifically for sentinel lymph node mapping.
It binds with a higher affinity and has a longer intravitreal half-life than ranibizumab and bevacizumab.
In particular, the 3′ overhang, 5′ overhang, and 5′ flap were bound with a much higher affinity than the other substrates tested (Fig. 1D).
Fgfs also bind with a relatively high affinity to heparan sulphates, which in general are present as covalently linked side chains on cell-surface proteoglycans.
All tested ML bound with high affinity in a unique site, within the inner chamber of the protein, supporting that ML may be transported by Cel-Pgp-1.
One of the engineered variants (WN-Fc), bound with high affinity to a wide range of solid tumor cell lines (e.g., colon, lung, prostate, skin, ovarian, and mammary tumors).
In a previous study we demonstrated that the alternatively spliced region of tenascin-C, TNfnA-D, bound with high affinity to a cell surface receptor, annexin II.
