Sentence examples for bound to wild type from inspiring English sources
Binding free energies and thermodynamic property differences for nevirapine bound to wild type and Y181C HIV-1 reverse transcriptase were investigated, and the results were compared with available experimental data.
FBXW8 was associated with both cyclin D1 wild type and the T286A mutant, but the majority was bound to wild type, which was mostly phosphorylated at Thr286.
Simultaneous binding of dasatinib and GNF-5 to T315I caused conformational and/or dynamics changes in Abl such that effects of dasatinib on T315I were the same as when it bound to wild type Abl.
When immunoprecipitation was performed in HeLa cells that were transfected with PLD1 constructs after depleting endogenous PLD1, μ2 bound to wild type PLD1, but not to R304A or R304K mutant (Figure 3B).
As we and others reported previously, the percentage of GTP bound to wild type Rap1A is around twenty percent, while Rap1A-V12 is highly GTP-bound [ 13, 32].
The biological activity of the mutated peptides was estimated from the transient mobilization of the intracellular calcium concentration, which was mediated by the receptors bound to wild type and mutated peptides.
Immunoprecipitation using these mutants revealed NDRG1 specifically binds to wild type and GTP-bound Rab4aQ67L but does not bind to the GDP-bound Rab4aS22N mutant corroborating our in vitro pull-down experiments (Figure 4A).
10.7554/eLife.03574.016 Figure 5. Lamotrigine binds to wild type but not mutant IF2 in a G-nucleotide-dependent manner.
Finally, in a combination experiment, hydrogen exchange in the T315I protein in the presence of both dasatinib and GNF-5 demonstrated changes in exchange near the ATP site that were nearly the same as those seen when dasatinib bound to wild-type Abl.
As in AfUGMF66A-UDP, the conformation of UDP bound to AfUGMN207A is essentially identical to that bound to wild-type AfUGM.
