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Structures of CS-35Fab bound to two additional tetrasaccharides confirm the general mode of binding seen in the hexasaccharide and indicate how different parts of LAM are recognized.
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Besides death receptors, TRAIL can also bind to two additional plasma membrane-bound receptors, TRAIL-R3 and TRAIL-R4.
CtrA also binds to four additional sites downstream of the S6 TSS suggesting a complex mechanism of autoregulation.
We also observed an additional minor component at higher MW (m/ z 17148 Da), resembling PanZ bound to two equivalents of CoA – we hypothesise that this second species corresponds to PanZ bound to the covalent CoA disulphide.
x is bound to three.
AAbs bound to fifteen different retinal antigens.
Interestingly, Snail1 is unable to bind to four additional consensus boxes or to the three perfect-match E-boxes contained in 3 kb or between 7 and 8 Kb fragments upstream of the Runx2 coding region, respectively.
An X-ray crystal structure of enzymatically most potent molecule bound to LDHA revealed two additional interactions associated with enhanced biochemical potency.
The pipeline decision is bound to provide an additional irritant in relations between Washington and Islamabad.
This model, however, does not preclude the possibility of two additional molecules of p21 bound to the other two molecules of PCNA in the trimeric structure.
Other organic components of bone may be bound to fibrils and exert additional effects.
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