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We used smFRET to characterize the DNA conformations sampled when MutS or MutS-E41A is bound to three different DNA mismatches/IDLs that exhibit differences in repair properties: a single-thymine insertion (T-bulge), a GT mismatch, and a CC mismatch.
Recently, our group has expressed, purified and solved the three-dimensional structure of the alkanesulfonate-binding protein SsuA bound to three different alkanesulfonates.
We have determined the crystal structures of the bovine endothelial NOS dimer oxygenase domain bound to three different pterin analogues, which reveal an intimate structural communication between the H4B and Zn2+ sites.
For the BM3.3 TCR, although no structure is available for the free receptor, structures are known for the receptor bound to three different pMHC ligands: pBM1/H-2Kb [ 38], pBM8/H-2Kbm8 [ 39] and VSV8/H-2Kb [ 40].
Whereas a recent report found that C9ORF72 RNA with the repeat expansion bound to three different hnRNPs, hnRNPA1, hnRNPA2/B1 and hnRNPA3 (10), here we show that wild-type C9ORF72 also interacts with hnRNPs.
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The amine molecule bound initially to individual center rearranges gradually to configuration where amine molecule is bound to two different types of sites.
Here, we report the structure of AgBIS, a three-domain plant sesquiterpene synthase, crystallized in its apo form and bound to five different inhibitors.
Surface carbon sites of as-prepared GCNFs are oxidized to carboxylic acid groups by nitric acid and covalently bound to seven different linker molecules containing pendant amino groups using carboxylate amidation chemistry.
In this work, we present a molecular dynamics study on Mdm2 structure bound to two different known inhibitors with the aim to investigate the structural transitions between apo-Mdm2 and Mdm2-inhibitor complexes.
Subsequently, Poulos [22] studied LDL bound to five different antibodies at 4°C to a resolution of 25 Å.
This interface, termed interface V, is mediated by the loop region between helix A and helix B of GM-CSF bound to two different hexamers.
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