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We validate the predicted target regions of Grainyhead by ChIP-seq and identify this factor as a general cofactor in the eye network, being bound to thousands of nucleosome-free regions.
Our results support a model in which CREB is constitutively bound to thousands of target genes, and combinatorial interactions between DNA-binding factors are necessary to achieve the specific transcriptional response of the liver to fasting.
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The mammalian Myc oncoprotein is a transcription factor that binds to thousands of promoters.
Frontrunners in the targeted delivery arena are DNA Nanoparticles (DNs), such as DNA origami, which are composed of a long single-strand of DNA or scaffold that folds into any one of a variety of shapes and sizes when it binds to hundreds of short DNA strands, called staples.
They found that CHD8 binds to thousands of targets in each tissue.
Wnt proteins bind to seven-transmembrane Frizzled receptors to mediate the important developmental, morphogenetic, and stem cell related tissue-regenerative effects of Wnt signaling.
But changes to the health care law and Medicaid are bound to affect millions of its members negatively.
And its findings are bound to raise hopes for tens of thousands of families caring for unresponsive, brain-damaged patients around the world — whether those hopes are justified or not, experts said.
It means that except for the few groups or clusters which were already gravitationally bound to one another billions of years ago, no new ones ever will become so.
Its extraordinary 10% rate of growth is bound to slow to 8% due to the 12th Five-Year Plan, just in its inception stage.
If we deal with the history of the 20th century, we are bound to deal with it".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com