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The O,O,O donor atom triad of compounds show metal chelation with divalent Mg2+ ions bound to the three catalytic amino acids in the enzyme's active site and π-stacking interaction with the viral DNA residue DA17.
Crystal structures reported for Fe FbpABp–(oxalate 2 and Fe FbpABp carbonate show that Fe3+ is bound to the three conserved tyrosine residues on the C-lobe of the protein.
Compared with the IL-1β untreated control, ESE-1 loading onto the corresponding promoters was significantly enhanced after IL-1β stimulation, indicating that ESE-1 bound to the three predicted binding sites of GP73 promoter, and this binding activity was strongly enhanced by IL-1β treatment.
We observed that a product formed at pH = 7.4 indeed suffered from instability indicating that at this pH a certain amount of weak complexes are formed containing partly hydrolyzed Ga ions and so being only mono- or bidentate bound to the three hydroxamate functions.
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The copper (II) concentrations bound to the two SHQs were 347 mol/g and 76 mol/g, respectively.
Relative energy calculations performed at different levels indicate that the most stable complex holds the structure, in which two lithium cations are bound to the two oxygen sites of the glycine zwitterion.
Moreover, seven N-glycosylation sites were found in the structure, and 49 glycans bound to the two ZoPrx molecules found in the asymmetric unit are clearly visible in the electron density map.
We also report significant variation in the pose and disparate binding affinities for the Gdm radicicol chimera radamide when bound to the two paralogs, which may be exploited in the design of paralog-specific inhibitors.
The remainder of the CKI-7 inhibitor, the aminoethyl-sulfonamide, adopts different conformations when bound to the two APH enzymes.
Two resorcinol molecules are respectively bound to the two C-domains of the RolR dimer and the resorcinol-binding pockets are identical in both monomers.
Aluminium is bound to the four fluoride ligands in a square planar coordination.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com