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In this work, the relevant quantity we compute has a clear physical interpretation: the average number of TF molecules bound to the sequence.
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Multiple HD transcription factors cooperatively bind to the sequences upstream of GnRH, regulating not only cell type specific expression but also dynamic, physiologic responses by serving as scaffolds for additional cofactors [26], [27].
The activation of the Hippo pathway kinases results in phosphorylation and inactivation of the downstream transcriptional co-activator Yorkie which binds to the sequence-specific DNA-binding protein Scalloped and enhances the expression of proliferative and pro-survival genes.
Consensus sequences were bound to the coding sequence using as reference the sequence of Mus musculus retrieved from NCBI GenBank (accession number NM_139301).
In the study (Demars et al., 2010), OCT4 is shown to be bound to the wildtype sequence, but not bound in the mutated sequence.
The single-stranded molecules were bound to the Illumina sequencing chip and sequenced using Illumina HiSeq™ 2000.
Once the RNA is bound to the DNA sequence, Cas9 cuts the DNA at the targeted location and the cell's natural DNA repair mechanisms work to repair the DNA sequence.
It was shown that (i) TRB3 overexpression inhibits CHOP and ASNS induction by leucine starvation, (ii) TRB3 is associated with ATF4 in the protein complex bound to the AARE sequence.
(D ) Structure of HMPV M2-1 bound to the DNA sequence AGTT.
(B ) HMPV M2-1 core domain bound to the DNA sequence AG.
We have analyzed the promoter activity and a protein bound to the DNA sequence of the gene (13, 14).
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