As shown in Fig. 11B, neither NUP98-HOXA9 nor its N51S mutant bound to the HEY1 promoter, supporting the notion that its transactivation is independent of direct homeodomain-DNA interaction.
This is of course a logical expansion for Amazon to make, one that is bound to reinforce the notion that Kindle isn't simply a ereader device + ebook store but a true global ecosystem of writers and publishers.
These observations are consistent with the notion that PCBs bind to the DBD and subsequently change the conformation of the domain and its surrounding region to induce the dissociation from TRE.
Taken together, our data strongly support the notion that Myc directly binds to the promoters of many nuclear encoded mitochondrial genes and positively regulates the transcription of these genes.
Alternatively, however, MAD2B may travel across the nuclear membrane when bound to RAN, a notion that would be in agreement with our current PRCC co-localization assays and our suggestion that the respective MAD2B-PRCC and MAD2B-RAN interactions may be dynamic in nature.
But because he's not writing for news outlets or bound to regressive notions of journalistic objectivity, Lamar's work achieves something most reporters can't: It speaks from the prerogative of black communities facing oppression and directly attacks the institutions responsible for their pain.
The bonobo was no less a relative of humans than the chimpanzee, de Waal noted, and its behavior was bound to overthrow "established notions about where we came from and what our behavioral potential is".
"The bonobo was no less a relative of humans than the chimpanzee," one researcher explains, "and its behavior was bound to overthrow 'established notions about where we came from and what our behavioral potential is.'" "Mr. Kurtz, I Presume?" by Adam Hochschild, April 14 , 1997Hochschild surveys the harrowing history of colonial Zaire to unearth the original Kurtz.
It suggests as well the need to "subdue the self," k'e chi, what is bound to be a very unpopular notion in an age where "freedom of expression" dominates civility.
That is unlikely to happen in a "free" Scotland, where no one has been killed in pursuit of the cause, but when we learn that Burnside invoked the Scottish communist John Maclean, "appointed consul for Soviet Affairs in Great Britain" by Maxim Litvinov after the October revolution, we are bound to reflect that some people's notions of freedom are more freewheeling than others.
