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Aptamers bound to targets on both the infected-cell membrane, and the STIV envelope during the selection process.
There are currently many structures of ankyrin repeat proteins bound to targets, and all of them use short beta hairpins at the junctions separating repeats.
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This observation is consistent with the conformational preferences observed in other DNA aptamers that are bound to target proteins21.
MicroRNAs (miRNAs) interact with target sites located in the 3' untranslated regions (3' UTRs) of mRNAs to downregulate their expression when the appropriate miRNA is bound to target mRNA.
This technology uses customized nanoparticles bound to target specific oligonucleotide probes that form binaries in the presence of nucleic acid from the target microorganism.
Hence Aβ might remain bound to target molecules despite the falling extracellular concentrations of diffusible Aβ species.
However, in the basal state, ELK4 is already bound to target genes poised for zymosan induction.
It was expressed as the following ratio: aptamer pool bound to target-containing beads/aptamer pool bound to empty beads.
Fusion to Ig might facilitate expression, purification, as well as recognition of soluble TCRs bound to target pMHC.
Are IDPs always bound to target proteins, are they chaperoned, or are there pools of unbound IDPs?
Pgap1 catalyzes inositol deacylation after the GPI anchor is covalently bound to target proteins (Tanaka et al., 2004).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com