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We extend and formalize the approach through development of a multi-dimensional analytical model in which the folding reaction coordinate is defined by the number of denaturant molecules bound to sites located on either the initially folded, or unfolded, states of the protein.
In addition, Pch bound to sites throughout the LEE sequence, including the coding region of the LEE1 operon.
Indeed, RORγt was found to be almost exclusively bound to sites also bound by IRF4, BATF and STAT3 [ 56].
This abovementioned study showed that PU.1 bound to sites in the Il9 promoter specifically in Th9 cells and promoted the switch between Th2 and Th9 phenotypes.
On the other hand, STAT4/5/6 in T cells and STAT5 in liver tissues specifically bound to sites in the Cish downstream region.
Moran et al. [ 72] also concluded that the IgG LOS-induced anti-GM1 antibodies bound to sites at the nodes of Ranvier in humans.
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Warfarin and ibuprofen especially bound to site I and site II, respectively, were chosen as the site markers [23, 44].
Site-directed mutagenesis indicated that the toxin bound to site 4, which was located on the extracellular S3 S4 linker of hNav1.7 domain II.
Photoprotection by quenching of chlorophyll triplets is catalysed mainly by lutein bound to site L1, and occurs via energy transfer from chlorophylls A1 and B1.
HoxD13, however, only bound to site 2 in vivo.
The result indicated Hoxd13 is bound to site 2 in vitro.
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