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Less NF-κB bound to its specific probe in nuclei extracts from PALS1 siRNA transfected cells following TCR stimulation (Figure 4A).
We suggest that high NaCl-induced solubilization of chromatin-bound MDC1 could occur from pools not associated with TonEBP/OREBP, leaving MDC1 still associated with the TonEBP/OREBP bound to its specific DNA elements.
Apparently, extinction is bound to its specific context and does not generalize to the original learning context.
Vitamin A is primarily transported as retinol bound to its specific transport protein, retinol-binding protein 4 (RBP4) and retinyl esters (REs), contained in lipoproteins.
The first step in the degradation pathway is that the substrate (in this case MisP) is bound to its specific ubiquitin ligase (E3).
The 25(OH D is transported in the circulation, mainly bound to its specific vitamin D-binding protein, also named the GC-group component (GC).
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In an earlier study by Jauch et al (1996) uPAR is a glycosyl-phosphatidylinositol-anchored glycoprotein localised on the outer layer of the plasma membrane of cells, and it binds to its specific ligands such as urokinase-type plasminogen activator (uPA).
This complex then binds to its specific DNA recognition sites to activate the transcription of dioxin responsive genes (Hankinson 1995).
Cross-linking of allergen-specific IgE bound to its receptor FcϵRI induced a series of molecular events leading to NF-κB and MAPK activation and subsequent cytokine production [ 26, 27].
The cross-linking of allergen-specific IgE bound to its high-affinity receptor FcϵRI results in a series of molecular events leading to NF-κB activation and subsequent cytokine production [ 26, 27].
Addition of a kinase inhibitor to the cell lysates enables it to bind to its specific target(s), occupying the binding sites and preventing binding to the kinobeads, whereas the binding of nontargeted kinases and other proteins are unaffected.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com