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In the atopic environment, mast cells are activated by binding antigen to the IgE that is bound to its multimeric receptor, FcɛRI.
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Its beauty is bound to its fragility.
Each antibody correctly bound to its corresponding protein.
Leptin exclusively binds to its receptor, OB-R.
"London is bound to lose its independence".
It is bound to look to its own security.
Chromatin immunoprecipitation in HeLa cells at the G1/S-phase transition indicates that all six MCMs colocalise on shared DNA fragments of 500 base pairs, advocating that these proteins are bound to chromatin as a multimeric complex containing all six subunits (Ritzi et al, 1998).
In support of this idea, it was demonstrated that M2 monoclonal antibodies which preferentially bind to M2 multimeric forms but not the monomeric form were protective, and that this was independent of natural killer cell mediated effector functions [35].
And in the nitrogen assimilation case, robustness depends on avidity of the bifunctional enzyme to its multimeric substrate.
The robust mechanism is based on avidity of the bifunctional enzyme RP to its multimeric substrate PPDK, and on a product-inhibition feedback loop that couples the system output to the activity of the bifunctional regulator.
The mechanism depends on avidity of the bifunctional enzyme RP to its multimeric substrate PPDK, and on a product-inhibition feedback loop that couples the system output PEP formation rate to the activity of the bifunctional regulator.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com