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The fatty acids (free or bound to fatty acid binding proteins) can therefore diffuse directly into the cells, potentially explaining why the fatty acid substrate was metabolized so efficiently at this stage (Fig. 5).
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Our results suggest that the HNF4s may be transcription factors that are constitutively bound to fatty acids.
Palmitate was prepared in a solution bound to fatty acid-free bovine serum albumin (BSA).
The eel protein lights up when it binds to fatty acids such as bilirubin, a key blood compound that helps clear waste products generated by the breakdown of aged red blood cells.
The human ALBU also binds to fatty acids with high affinity as it has several polymorphic forms with long hydrophobic pockets that are distributed asymmetrically throughout the repeating domains of this protein [111], [112].
Of course, we also found other up-regulated PPARG targets, such as the transcripts coding for fatty acid-binding FABP4 [ 32] and PLIN, which binds to fatty acids in such a way that lipid droplets are formed and fatty acids are protected against degrading enzymes [ 33].
Vertebrate SCP-2 binds to fatty acid and cholesterol [ 26].
Osmium tetroxide binds to fatty acids to form a black osmium dioxide residue and thus, is was once used to reveal fingerprints.
LTP4, a gene of lipid transfer proteins gene family, could bind to fatty acids and transfer phospholipids between the membranes (Arondel et al. 2000).
Since FABP5 binds to fatty acids with high specificity, there is a breakdown in the storage of fats during lipolysis, resulting in the release of free fatty acids into the bloodstream [87].
Cytochrome c-550 binds to fatty acids of C15, C16, and C17 chain lengths via glycerol-Cys.
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