Sentence examples for bound to different targets from inspiring English sources

The latter retrieved different but related macrolides bound to different targets.

The hits were bound to different targets including ribosomal subunits, macrolide biosensor proteins, macrolide glycosyltransferases, multidrug exporter protein and cytochrome P450.

(E) Statistical analyses of the target number of ligands included in the MTLD: 795 ligand entries bind two targets; 551 ligand entries bind 3 5 targets; 189 ligand entries bind 6 10 targets; and 197 ligand entries bind to >10 targets; (F) Comparison of the conformation of a ligand bound to different targets.

mAbs that bind to different targets may not be directly comparable based on pI alone; individual mAbs against different targets have their own physicochemical characteristics that may uniquely contribute to PK properties.

Moreover, since different aptamer can specifically bind to different target molecules, the designed strategy has an expansive application for the construction of versatile PEC platforms.

Based on the mechanisms of action, dual-targeting BsAb can be constructed to bind to different targets of the signaling pathways within the same diseased cells.

This (indirect) diversity measure has its disadvantages as similar ligands can bind to different targets or alternatively, structurally diverse ligands may bind to the same target.

Since a compound may be able to bind to different targets in different conformations, the algorithm aligns pairs of pharmacophore models sharing the same features which are not necessarily at the exactly same spatial distance.

Toxins that share similar structures, despite no notable sequence similarities, bind to different targets (e.g. CcdB binds to DNA gyrase but Kid, which has similar structure as CcdB, cleaves free mRNAs) (Hargreaves et al., 2002).

BsAb can also be designed to bind to different targets expressed on different cell populations within the diseased tissues to achieve synergistic therapeutic effects and/or to enhance specific tissue distribution [55].

Individual models for each heavy metal showed variance in the variable importance, indicating that the targeted heavy metals were bound to different sediment fractions.