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A very good enrichment was also observed for tetracycline (Fig. 2b) and the results comprised different tetracycline derivatives bound to different proteins (tetracycline repressors, Tetx monooxygenases, multidrug binding protein, elongation factor Tu, ribosomal subunit and a tetracycline aptamer).
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The researchers confirmed the identity of these cells by staining the lab-grown tissues with fluorescent antibodies that recognize and bind to different proteins synthesised only by each cell type.
Date hubs bind to different proteins at different times.
The individual WD40 repeats can simultaneously bind to different proteins, making Rack1 a candidate platform for integrating several signaling pathways.
Noting that the sequences surrounding pY279 in GSK-3α and pY216 in GSK-3β are identical, these results suggest either that each antibody recognises a different pool of tyrosine-phosphorylated GSK-3 or that they bind to different proteins, which raises questions about their specificity.
Computed RMSD values of most MTLs (1,270 entries, ≈73.3%) were <2.0 Å (Figure 2F), indicating that most of the MTLs could bind to different proteins by adopting a similar conformation.
Aptamers are short strands of synthetically designed DNA or RNA oligonucleotides that can be self-assembled into unique 3-dimensional structures and can bind to different proteins, cells or even small molecules at a high level of specificity and affinity.
Different types of zinc fingers may bind to different proteins or histones [ 54] and be recruited to different target areas of chromatin.
Biochemically, PDCD10 is an adaptor protein that can bind to different proteins and/or protein complexes such as CCM2; each of three germinal center kinases III (GCKIII) serine/threonine kinases (STK24, STK25 and MST4); paxillin and VEGFR2 [ 7].
Plasma Aβ is well known to originate in different organs and it also is known that Aβ binds to different proteins and cells in the blood, thereby possibly accounting for why plasma Aβ levels do not correlate with Aβ measured in CSF or CNS plaque burden measured by PET amyloid plaque imaging.
Johnson et al. have now revealed the three-dimensional structure of one nucleoside transporter protein bound to different nucleosides and nucleoside-derived chemicals, including three anti-cancer drugs and one anti-viral drug.
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