Sentence examples for bound to different ligands from inspiring English sources

Writing in Nature, Laverty et al.1 and Masiulis et al.2 report the 3D high-resolution structures of an isoform of the GABAA receptor bound to different ligands in physiologically relevant conformations.

To optimize a lead compound, research labs need to routinely and rapidly solve dozens of structures of a protein bound to different ligands, to find which offers the most favourable interactions.

Using "monobodies," small antibody mimics based on the fibronectin type III domain, as the target-binding proteins, we demonstrated the effectiveness of our method by separating the active form of the estrogen receptor α ligand-binding domain (ERα-LBD) from a mixture of active and misfolded species and by discriminating two different conformations of ERα-LBD bound to different ligands.

One problem with the non-redundant PFAM dataset is that the same or different proteins representing the same Pfam domain and bound to different ligands appear as different entries in the database.

We primarily discuss TCR CDR loops, initially examining how loop flexibility and dynamics might influence TCR specificity and cross-reactivity, but also comparing loop positions in cases where the same receptor is bound to different ligands.

Molecular modeling was assessed using MOE software (Molecular Operating Environment Chemical Computing Groupp, Inc .. Two PDB Protein Data Bankk; http://www.wwpdb.org/) crystal structures, 4EMA and 2HFP, constituting the human PPARγ ligand-binding domain bound to different ligands, were compared.

Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes.

Although they bind to different ligands, they identify each other during sequence searches and display 23 29% sequence identity.

Nrps are known as multi-functional co-receptors that bind to different ligands in different cell types (Gu et al., 2003; Gitler et al., 2004; Pellet-Many et al., 2008).

However, because complexes of two different ligands bound to different type I receptors were compared here, the nature and significance of this change in ligand receptor architecture remained unclear.

RACK1 forms a propeller-like structure that contains seven "blades" (domains 1 to 7), which consist of WD40 repeats that can bind to different ligands [42].