On the other hand, at least some of the low affinity, nonspecific antibodies contains binding sites that are disordered in isolation but become differently folded when bound to different partners.
Previous structural studies of EGFR-TKD bound to different TKIs [ 8] suggest that individual drugs differ in their preference for the 'active' compared with 'inactive' conformation of the kinase, although they are all strictly type I TKIs [ 9] in that they bind EGFR-TKD in the 'DFG (Asp-Phe-Gly -in' conformAsp-Phe-Gly -in'
Indeed, molecular accommodation was apparent in solved structures of individual TCR bound to different pMHC complexes or when comparing free and pMHC-bound TCR [11].
While HA glycan X-ray cocrystal structures revealed differences in overall glycan topology (cone-like vs umbrella-like), when bound to different HAs, these "static" structures did not entirely capture the restrictions imposed on the conformational space of the glycan receptor by the RBS of different HAs, in moving from the free to HA-bound state.
Both men were contractually bound to different promoters and cable television companies.
a, Example AFM image of SpCas9 bound to different points on a single, streptavidin-labeled DNA molecule.
As it turned out, Florida, South Carolina and Louisiana each sent two slates of electors, bound to different candidates, to Washington.
Still more studies indicated that insulin and visfatin bound to different spots on the same protein (the insulin receptor), which, when activated, causes cells to take in glucose.
In a Pharmacokinetic reaction a ligand may be bound to different types of macro-molecules, each with different number of binding sites.
According to an enactment specification, different instances of the same activity can be bound to different services to achieve enactment flexibility.
Individual models for each heavy metal showed variance in the variable importance, indicating that the targeted heavy metals were bound to different sediment fractions.
