"Before you start promulgating this and marketing it and profiting from it, you should ethically be bound to demonstrate it scientifically in a peer-reviewed, respected journal," Kirsch said, and then you must have it tested by others.
RCN General Secretary Peter Carter said nurses were bound to "demonstrate their serious concerns" about the NHS in a Q&A session with Mr Lansley.
I think that some people, maybe thoughtlessly, let that happen". He adds that he believes in "a carefully defined sphere for public activity," and within that sphere, "we are duty-bound to demonstrate effectiveness and spend every dollar very wisely". As governor, he has been trying to translate that philosophy into changes that taxpayers can see.
To the best of our knowledge, this represents the first report of a high-resolution structure of a small-molecule inhibitor bound to NC, demonstrating sub-micromolar potency and moderate antiviral potency with one analogue of the series.
The crystal structure of PKM2 bound to phenylalanine demonstrates that the amino acid could lock PKM2 in an inactive T-state (Morgan et al., 2013), while the crystal structure of PKM2 bound to serine demonstrates that the amino acid could also allosterically activate PKM2 (Chaneton et al., 2012).
X-ray analysis of 5 bound to CK1δ demonstrated its binding mode.
We have shown that AtWhy2 is constitutively bound to mtDNA demonstrating for the first time that Whirlies can associate with DNA in organelles.
In this age of the "starchitect," that is bound to change, as demonstrated by two new dramas that present — and then undercut — the persona of the uncompromising visionary who dreams up buildings.
Acid treatment efficiently eliminates any ligand bound to uPAR as demonstrated in [11].
The internalization may have occurred with lipase bound to HSPG, as demonstrated with cultured fibroblasts and with hepatocytes [ 32, 35, 36] and/or with lipase bound to LRP as suggested by several authors [ 24, 25, 35, 37].
In line, HBsAg preferentially bound to TLR9-triggered pdemonstratinging that once pDC are able to bind HBV/HBsAg, the virus exerts its immune regulatory effect.
