Sentence examples for bound to complement from inspiring English sources

Complement deficiencies and low levels of immunoglobulins observed in CLL could contribute to impaired retention of self-antigens bound to complement and/or antibodies (immune complexes) in the bone marrow and spleen, having a negative impact on central tolerance mechanisms and contributing to the selection of autoreactive clones that are related or unrelated to CLL (Fig.  4).

The starting coordinates of variant E1 of Compstatin bound to Complement component C3c were taken from PDB: 2QKI.

TT30 is constructed from the first four short complement regulator (SCR) domains of complement receptor type 2 (CR2) that bind to complement C3d, followed by the first five SCR domains of complement factor H that bind to complement C3b.

The rationale was that NMO-IgG recognizes an extracellular epitope of AQP4, binds to complement, and leads to the internalization of AQP4 in vitro [15].

One aspect of this process utilizes the complement system, in which C3b-opsonized immune complexes bind to complement receptor type 1 (CR1) on RBCs in primates or to complement factor H in rodents [14], [15].

AM is secreted into the circulation, where it binds to complement factor H [ 3].

Sequentially, autoantibodies bind to complement fragments, which have a major functional consequence to cause tissue injury, especially in the kidney [ 39, 40].

The TED domain also binds to complement receptors types 1 and 2 at different contact sites, and these may be affected by missense mutations in the TED domain [ 92].

SGGS_124 also possesses genes encoding immunoglobulin G binding protein (SDEG_1358) [ 45] and multifunctional streptococcal plasmin receptor (Plr)/streptococcal surface dehydrogenase (SDH /glyceraldehyde-3-phosphate SDH /glyceraldehyde-3-phosphate SDH /glyceraldehyde-3-phosphate(Sdehydrogenase6] (Additional file 6), althouGAPDHe product of SDEG_1936 lacks a signal peptide.

Regarding CIC bound to complement-derived CR1 ligands, the increased levels of C1q-CIC in schizophrenia patients compared to healthy controls were detected, whereas no significant difference in the levels of C3d-CIC between patients and controls was observed.

The poxviral complement control protein VCP (vaccinia virus complement control protein) can bind to complement components C3b and C4b, respectively, thereby inactivating complement components or blocking the formation of the C3 convertase complex [8].