DSG2 was also shown to be unable to bind HAdV-D26K or HAdV-D48K at any concentration by SPR.
μ-Calpain cleavage of NCS-1 occurs within an N-terminal pseudoEF-hand domain, which by sequence analysis appears to be unable to bind Ca2+.
Ni II) appears to be unable to bind this backbone amide, and as a result, this metal is unable to induce the formation of β2m oligomers or amyloids.
Figure 2f shows that Wig-1 binds to the N-Myc 3′UTR probe but not to the control probe, while a zinc finger point mutant form of Wig-1 which cannot bind to RNA is unable to bind to any of the biotinylated probes.
Notably, Cu10MT-2A alone was not toxic to neurons (Figure 5A), confirming that when copper is bound to MT it is unable to produce ROS.
Although the isolated VHH that bind to gD2 are unable to neutralize HSV-2 on their own in a monomeric form, they can be used to specifically deliver other effector proteins resulting in potent antiviral activity against HSV-2.
Moreover, the PY mutant of RNF11 which does not bind to Smurf2 is unable to restore the activation of the 3TP reporter.
When bound to LapD, LapG is unable to break apart the molecules that help P. fluorescens cells bind to a surface, and so a biofilm can form.
Alternatively, blocking endogenous auto-antibody binding with aquaporumab, which binds to AQP4 but is unable to activate complement or interact with effector cells [ 53] may be beneficial.
A receptor that is already bound to a LPS molecule will be unable to receive another one.
The syt 7 4D/N mutant, which fails to bind Ca2+, was unable to rescue SV replenishment in KO neurons, suggesting that syt 7 functions as Ca2+-sensor during replenishment.
