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In addition to using firewalls for this purpose, Wu et al. [20] also employ subnetting (i.e., each virtual network is bound to a unique subnet) in order to provide an additional layer of security against unauthorized information disclosure.
The antigen for HCAb2 was found to be HSP90 and HCAb2 bound to a unique subset of xenograft tumor cells that were negative for calnexin.
The major sequence deviation of animal rhodopsins from non-opsin GPCRs might result from the need to re-accommodate the retinal moiety (see Fig. 2), which is bound to a unique Lys7.43 residue that is located on the same 7th helix as retinal-binding Lys residues in MRs [ 2] but does not align with them either in the standard or alternative alignment (Fig. 1f, Additional file 1: Figures S4, S10a).
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It binds to a unique ligand, ICOSL, and does not bind to other ligands such as B7-1/B7-2 B7-1/B7-2 B7-1/B7-2
These agents bind to a unique receptor found on the intestine epithelial cells, called guanylate cyclase C (GC-C, also known as STA receptor).
Like trastuzumab, pertuzumab is a HER2-targeted humanized monoclonal antibody; however, it binds to a unique epitope in the dimerization domain and has a complementary mode of action to trastuzumab [ 8, 9].
REST is unique: it binds to a unique sequence that allows identity of the binding sites both bioinformatically and by ChIP; the gene targets represent a large set of proteins that are essential for terminal neuronal differentiation, a specific transition during differentiation; and REST is present in ESCs, where these targets are repressed, and minimally expressed at terminal differentiation.
This mAb binds to an unique epitope on HBsAg and potently suppress levels of HBsAg and HBV DNA for several weeks in HBV transgenic mice (Zhang et al., 2016).
Hence, FOXM1 also bound to a significant number of unique sites, suggesting that FOXM1 might uniquely control the transcription of specific sets of genes in a manner independent from ERα or that ERα might operate along with FOXM1 present at different sites via looping together of different chromatin locations.
High-resolution X-ray crystal structures revealed that both proteins bound to an essentially identical epitope, providing a unique opportunity to directly investigate the role of amino acid diversity in a protein interaction interface.
The nCounter® system works by directly capturing and counting individual mRNA transcripts using a target sequence bound to an immobilization bead and possessing a unique barcode.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com