Crystallographic structures of aminoglycosides bound to A-site systems clarified many static aspects of RNA ligand interactions.
We previously reported the structure of IgFLNa21 bound to a peptide from the integrin β7 cytoplasmic tail (PDB code 2BRQ) (Kiema et al, 2006), and comparison of the two IgFLNa21 structures reveals good alignment of the β-strands (r.m.s.d., 0.60 Å for 40 Cα atoms) but BC and DE loops differ (overall r.m.s.d. 1.67 Å for 91 Cα atoms).
We have determined the structure of Scc4 bound to a minimal fragment of Scc2, and we have used this structure to derive separation of function alleles that uncouple cohesin loading from cohesin targeting to centromeres.
Its light-transmitting skylights and louvers are supported by a steel structure bound to a series of 29 laminated bands of Douglas fir, 100 feet long and 10 feet apart, whitewashed to mute their naturally reddish tone.
They demonstrated that for human immunodeficiency virus-1 protease (hiv-1p), there is more structural variation between 28 structures in an NMR ensemble than between 90 crystal structures bound to a variety of ligands.
The overall fold, secondary structural elements, tertiary structure, and subunit assembly are identical to those of the previously determined structure of ZmPDC bound to a degraded form of ThDP (PDB entry 1ZPD).
A crystal structure of 1 bound to a Cys25Ser mutant of cathepsin S helped to elucidate the binding mode of a previously disclosed series of pyrazole-based CatS inhibitors and facilitated the design of a new class of arylalkyne analogs.
Since self-driving technology is bound to an idea of structure, it's simply easier to deploy the tech in a structured environment -- quite like the one that Singapore has.
A 2.2 Å X-ray crystal structure of 1a bound to a mutant form of Lck SH2 domain provides insight regarding the structure activity relationships and supports the design concept of this new pTyr mimetic.
Another team in 2008 determined the structure of linezolid bound to a 50S subunit of Deinococcus radiodurans.
Based on the X-ray crystal structure of CPX bound to a mimetic of this half-zippered intermediate in which only the N-terminal portion (residues 26 60) of v-SNARE, VAMP2, is present (SNAREΔ60), we proposed a molecular model for the clamping of the SNARE assembly by CPX (Kümmel et al., 2011).
