Sentence examples for bound to a small from inspiring English sources

The structure of a protein bound to a small molecule has helped to guide drug development chemistry, he says, work that he hopes to publish soon.

Girls like Sarjeena, who is 10 years old and was bound to a small tent taking care of her younger siblings.

To assess this point, we measured the root mean square deviation (rmsd) between the bound partners, the equivalent free forms and the form bound to a small molecule inhibitor for each complex family (Table 2 and Table S1).

First, a modified form of CRM1 was crystallized once it had bound to a small fragment of protein that contains a class 3 nuclear export signal.

Hypersensitive DNase, H3K4me2, H3K4me3, H3K9ac and H3K27ac, which are related to transcriptional activation, bind to > =80% H2H pairs; while H3K27me3 and H3K9me3, which are associated with gene silencing [ 26 ], are only bound to a small fraction of H2H gene pairs.

The flexible spatial scan statistic is similar to the method of the CSS except now the detected cluster is flexible in shape while still being bound to a small neighbourhood of each region.

This localization is in turn dependent on the Homer family of scaffolding proteins which bind to a small motif on the distal C-termini of mGluR1 and 5, localize the receptors near the PSD, strengthen coupling to post-synaptic effectors and simultaneously uncouple the mGluRs from extra-synaptic effectors such as voltage dependent ion channels.

Through their C-terminus, Cullins constitutively bind to a small RING finger protein, either RBX1 or RBX2, which forms the catalytic core of the ligase complex.

PBM assays defined the specific sequences that are bound by these HDs, revealing that the majority of binding sites contain TAAT core sequences that are shared by all FCI-HD TFs, but that each HD also binds to a small number of unique, atypical sequences.

The BMCC1 C-terminal isoform BNIPXL binds to a small GTP-binding protein RhoA and Lbc, a RhoA-specific guanine nucleotide exchange factor (RhoGEF), through its BCH domain, leading to the inhibition of RhoA-dependent stress fiber formation and malignant transformation.

Analysis of similarity between canonical homeodomain TF binding specificities between fruit fly and mammals using these existing datasets suggested that fruit fly homeodomains bind to a smaller subset of sites than human homeodomains.