Sentence examples for bound to a regulatory from inspiring English sources

RA binding to RAR/RXR heterodimers bound to a regulatory DNA element leads to a cascade of events resulting in recruitment of transcriptional co-activators and initiation of transcription [35], [37].

The side chain of Lys285, located in the αH-αI Loop of the large lobe, is typically solvent exposed and often disordered in crystal structures where the C-subunit is not bound to a regulatory subunit.

Different from existing thermodynamic models, STAP explicitly expresses the expected number of TFs bound to a regulatory sequence, and thus it is directly applicable to analyze binding intensities reflected in whole-genome binding data.

Finally, phylogenetic analyses support previous suggestions about the existence of an ancient bifunctional biotin-protein ligase bound to a regulatory transcription factor.

The CFTR ATP-dependent chloride channel is a 1480-residue monomer containing two membrane-spanning domains (MSD1 and MSD2, each with six transmembrane helices) alternating with two cytosolic nucleotide-binding domains, one of which is bound to a regulatory region (NBD1-R and NBD2; Fig. 2) (Mornon et al., 2009).

These techniques include chromatin immunoprecipitation (ChIP), which purifies fragments of DNA that bind to a regulatory protein, such as a transcription factor or a covalently modified histone.

The transactivation of the ISGs is controlled via the JAK/STAT signaling pathway either by an IFNα/β-activated TF complex termed ISGF3 (composed of STAT1, STAT2 and IRF9), which binds to a regulatory element denoted as ISRE (IFN-stimulated response element) [ 5, 6], or by an IFNγ-activated STAT1 homodimer complex, which binds primarily to the GAS regulatory element [ 7].

Mechanistically, noncompetitive antagonists are considered better suited for a more selective blockade of AMPA receptors, because noncompetitive antagonists bind to a regulatory site(s) distinct to the agonist site and their actions should not depend on the concentration of an agonist.

The eukaryotic 26S proteasome is composed of a 20S barrel shaped catalytic core in which the enzymatic protease sites located within the barrel lumen are bound to a 19S regulatory cap structure.

Therefore, changing the ETS factor bound to a cis-regulatory element can alter MAPK regulation of gene expression.

The coat color in turn depended on how many methyl groups were bound to a stretch of regulatory DNA just upstream of the Avy gene, suggesting that the methylation status was inherited epigenetically.