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Sp1 bound to a large number of sites (supplementary material Fig. S5A), most of which were promoters (Fig. 5A).
Alternatively, the crystal structures of several orphan receptors such as HNF4 were found to have a phospholipid constitutively bound to a large ligand binding pocket [ 5, 6].
A statistically relevant hit to a binding site bound to a large ligand with smaller cognate similarity might offer equal or greater relevant functional clues as a hit to a smaller ligand with greater cognate similarity.
ERα subpockets were generally highly conserved across the aquatic species (94 100%, Figure S5, Supporting Information), with the exception of T. rubripes for subpocket 8, which is bound to a large estradiol metal chelate ligand (88%).
Both of the absorption maxima were red-shifted as compared with 715 and 780 nm for ICG-sOSu, which is in agreement with previous publications where dye was bound to a large molecule.
While more rigorous investigation is required for validation, the correlation suggests that NADH component 4 may represent a formulation of NADH bound to a large mitochondrial enzyme, and could be a more specific indicator of changes in oxidative metabolism.
Similar(54)
Every look, every movement bound to a larger purpose.
Two peptides behaved as universal epitopes since they bound to a larger number of HLA-DR molecules.
The MAb 11A8 bound to a larger portion of cells infected with HIV-1 clade B, with higher mean channel fluorescence, than to uninfected cells (Figure 6).
Scavenger receptors bind to a large range of molecules on the surface of bacterial cells, and Toll-like receptors so called because of their similarity to well-studied receptors in fruit flies that are encoded by the Toll gene bind to more specific molecules.
As a result, it binds to a large number of partners, usually by recognizing phosphoserine or phosphothreonine motifs.
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Justyna Jupowicz-Kozak
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