Sentence examples for bound to a guide from inspiring English sources

(B ) Crystal structure of Ago2 bound to a guide RNA (red) and target RNA bearing t1A nucleotide (blue; PDB ID: 4W5O).

Recent crystal structures of Ago bound to a guide strand and its target RNA further highlighted the significance of the A-form helix in RISC catalysis.

We recently reported crystal structures of human Argonaute2 (Ago2) bound to a guide RNA and short, seed-paired target RNAs (Schirle et al., 2014).

In humans, RISC is minimally composed of a guide miRNA bound to an Argonaute protein (Ago 1, 2, 3 or 4), along with Dicer and the HIV transactivating response binding protein (TRBP) [16] [24].

The U-rich tail of guide RNAs bind to a purine-rich region in unedited pre-mRNA to generate recurring 5′AGA/3′UUU motifs that may help RNA editing proteins bind to the major groove.

The formation of box C/D and H/ACA nucleoproteins that direct site-specific methylation and pseudouridylation respectively are initiated when L7Ae-type proteins bind to a K-turn located in the guide RNA [50,51], followed by other proteins in an ordered process.

The CRISPR/Cas system is a promising technique for genome engineering which allows target-specific cleavage of genomic DNA guided by Cas9 nuclease in complex with a guide RNA (gRNA), that complementarily binds to a ∼20 nt targeted sequence.

Now he tells us how he did it, in a book that is bound to be a future guide for global investors, bankers and finance ministers.

Liu et al.[10] deduce a boosting error bound to guide the tracker construction and semi-supervised learning in Adaboost framework.

Since the A. fulgidus templates represent better resolution structures, the final illustrated Ago2 models are based on the mid domain from A. fulgidus Piwi alone [PDB: 1w9h] and bound to double-stranded guide [PDB: 2bgg].

Nevertheless, the recent solution of the crystal structure of the Cas9 protein bound to guide RNA and substrate DNA showing the mode of interaction between the PAM site and the Cas9 protein will hopefully facilitate directed evolution studies to re-engineer the PAM sequence requirement or even to completely remove the PAM dependency [ 87, 88].