SRF can also bind to a distinct promoter element found in many genes that encode actin cytoskeleton associated proteins [19].
It binds to a distinct region of the NMDAR.
Of 25 compounds in the 2-amine test group, only one (CF17) retained binding, but this hit produced a distinct CSP pattern (see below), indicating that it binds to a distinct site.
Transcription factors bind to a distinct point of the chromosome in a cooperative manner and recruit RNA polymerase II and other proteins forming a large transcription initiation complex, and finally make the RNA copy of the gene in question.
It is established for other GPCRs, such as formyl peptide like 2 (FPR2), that the proinflammatory serum amyloid A (SAA) binds to a distinct site on the receptor to the anti-inflammatory protein AnxA1 [13,53]; thus, one cannot conclude that lack of chemerin displacement by RvE1 and/or C15 means that these mediators are not ligands for the receptor.
Interestingly, they found that TcPIWI-tryp bound to a repertoire of RNAs distinct from siRNAs, namely small RNAs derived from rRNAs and tRNAs [ 23].
Instead, it binds to a largely distinct, and broad, set of genes.
Mature NTs also bind to a structurally distinct receptor, p75, which affects neuronal development through downstream signaling.
Although this compound has been used to delineate effects of FFA2 (34, 34), it clearly binds to a site distinct from the SCFAs and acts as a positive allosteric modulator of the action of the SCFAs, as well as a direct agonist (21, 33).
