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Thus, p53 phosphorylated at S46 is bound to a broad spectrum of target genes of which the apoptosis genes constitute a specific subset.
Already before autovaccination, the study patients had serum antibodies that bound to a broad antigen spectrum of their infecting S. aureus strain.
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In contrast, corepressors bind to a broad region of TRs, including the hinge region that is located immediately adjacent to the DBD.
The second benefit from biologically applying CNTs is the ease with which they bind to a broad range of molecules thanks to the extremely high reactivity of CNT surfaces.
Goldhill said all NHS managers are bound to an agreed set of principles that ensure the retention of a broad knowledge base.
It's smart, cool looking and is bound to have a broad range of appeal.
Nevertheless, the pharmaceutical firms now seem to have little option but to move even further towards some form of differential pricing.This is bound to have a broader effect on how pharmaceutical firms market and sell their drugs around the world.
Instead, it binds to a largely distinct, and broad, set of genes.
Haloperidol, a typical antipsychotic, is non-selective and binds to a broad range of receptors, exerting efficacy mainly through the antagonism of dopamine receptors.
TLR2 is expressed on many cell types and has been reported to bind to a broad array of microbial components [67], most notably lipoproteins [68], but also peptidoglycan [35], [69], and recently a bacterial porin [70].
It is well known that LILRB1 and LILRB2 bind to a broad range of classical and non-classical HLAIs [13], [14], [15] and major histocompatibility complex (MHC) class I-like molecules, such as UL18 [16].
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