Each riboswitch is then compared to a protein that binds the same ligand to contrast binding properties.
The ALDHs are known to have variable conformations between non-homologous proteins just like the ligand molecules, but it is also possible that the shapes of different protein binding pockets that bind the same ligand vary [31].
In the case of CXCR4, heterodimerisation with the chemokine receptor CXCR7, which binds the same ligand CXCL12, can alter both the kinetics and the dynamics of CXCR4 responsiveness to CXCL12 [51].
Many sites bind the same ligand in different proteins, so the number of unique ligands was 3659.
As all three FXRP family members bind the same ligand in vitro, we hypothesized that kcRNA might compete FXR1P and FXR2P off polysomes if all three also bind the same RNA ligand in vivo.
SDPclust predicts specificity in a phylogeny-independent stochastic manner, which allows for the correct identification of the specificity for proteins that are separated on a phylogenetic tree, but still bind the same ligand.
Since DR4 and DR5 bind the same ligand, it is not clear if and how they have specialized to mediate activation of the extrinsic apoptotic pathway in different contexts.
CD152 binds the same ligands like CD28, but has an affinity 10 50-fold 10 50-foldn thigher8 recepthanfor B.7-1 (CD80) and B.7-2 (CD86) molecules (Linsley ethel, 1994).
Next to CD28, T cells also express cytotoxic T-lymphocyte antigen-4 (CTLa4), a co-inhibitory molecule, which binds the same ligands as CD28 but with higher affinity [31,32].
For instance, transfection experiments with WC1-4 and WC1-9 would enable us to determine whether they bind the same ligands but their intracytoplasmic tails send different signals and thus result in differing functional responses.
