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Extended circulation times can exploit the EPR effect to enhance transport of AuNPs to the tumor site, while in parallel, the particles' bound targeting molecules increase the rate of endocytotic uptake [22, 25].
The modifications of preformed nanocarriers do not always lead to a controlled amount of bound targeting moieties, so other ways of coupling have been studied and the most important one is post-insertion method.
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Most antibiotics have to pass through these membrane channels to either reach cytoplasmic bound targets or to further cross the hydrophobic inner membrane.
GSEA comparison of directly bound targets with the NKX2.2 knockdown/rescue microarray dataset revealed a statistically significant enrichment of NKX2.2 bound targets with NKX2.2 repressed genes (NES = −1.4; p<0.001; Figure 5F).
In our study, we analyzed expression changes of p53 bound target genes using Affymetrix human exon arrays.
Recent reports have indicated that transcription factor binding is preferentially conserved when a bound target gene is required for a transcriptional regulator's function [23].
Thus, morpholinos are stable enough to persist throughout embryogenesis, irreversibly inhibiting bound target mRNAs.
We compared Miz-1 bound target genes to regions of H3K4me3 or AcH3K9 enrichment.
Using ChIP-chip analysis, we identified 3,498 putative direct Myc bound target genes (c-Myc and/or N-Myc bound).
Time bound targets have been promulgated, often without any reliable or systematic statistical system that permits tracking and monitoring.
Only 9.8% of IgG2a library reads mapped to the genome, likely reflecting the lower complexity of non-specifically bound targets.
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