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One molecule of elaidoylamide is bound simultaneously to the substrate binding sites of two associated neurotoxic phospholipase A2 molecules.
Also, molecular modeling and kinetic studies showed that compounds 5l and 5j bound simultaneously to the peripheral anionic site (PAS) and catalytic sites (CS) of the AChE and BChE.
This final structure contained two identical homodimers and one molecule of elaidoylamide bound simultaneously to the substrate-binding sites of each homodimer [ 74].
Finally, our observation that a single nucleosome can accommodate up to two bound ISWI enzymes raises several questions regarding the nucleosome repositioning activity of such a complex: if two ISWI enzymes were bound simultaneously to the same nucleosome, would only one or both be active during repositioning?
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Importantly, we present evidence that these proteins participate in multiple, distinct PRC1 complexes, that several PRC1 complexes bind simultaneously to the INK4a locus, and that their binding appears to be interdependent.
T-cell antigens bind simultaneously to the TCR/CD3 complex and the co-receptor CD8.
We have previously identified R-thiomandelate as a promising reasonably broad-spectrum inhibitor of MBLs, combining a thiol functionality which binds simultaneously to the two zinc atoms with a carboxylate function which increases its inhibitory potency [ 21, 27].
In E. coli, on the other hand, a polymerase "tool belt" model for switching pol III with pol IV at a stalled replication fork, where both polymerases bind simultaneously to the β-clamp, has been proposed.
These predictions show that there is virtually no Ste5 that are simultaneously bound to two kinases, such as Ste11 and Ste7 or Ste7 and Fus3 since on average there is usually less than one Ste5 molecule that is bound simultaneously to two of the kinases at a given time.
Occupancy levels for both GE and RifSV were 1, indicating that GE and RifSV were bound simultaneously to RNAP in the crystal.
Superantigens, including bacterial enterotoxins, are a family of proteins that bind simultaneously to MHC class II molecules and the Vβ regions of T cell receptors.
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