When binding of halothane and diazepam, which bind pocket 2, was studied by the MCMC method considerable pose diversity appeared to be present within the known binding pocket (Table 1).
Druggable microenvironments Most drugs bind pockets in targets whose physiological function involves binding endogenous small molecules.
Binding pocket of the c-di-GMP riboswitch.
Karaman, R. et al. Probing the Binding Pocket of the Broadly Tuned Human Bitter Taste Receptor TAS2R14 by Chemical Modification of Cognate Agonists.
West D, Kim CU, Tu C, Robbins AH, Gruner SM, Silverman DN, McKenna R, "Structural and Kinetic Effects on Changes in the CO(2) Binding Pocket of Human Carbonic Anhydrase II," Biochemistry; PMID: 23098192 Epub, (2012).
Tan, M. et al. Mutations within the P2 Domain of Norovirus Capsid Affect Binding to Human Histo-Blood Group AntigEvidencedence for a Binding Pocket.
Interestingly, the structure of the entire breakage-reunion domain revealed a new interaction, in which the Quinolone-Binding Pocket (QBP) is blocked by the N-terminal helix of a symmetry-related molecule.
Binding pocket S2 shows the most extensive differences.
USP: Ultraspiracle; ECR: Ecdysone receptor; LBD: Ligand Binding Domain; LBP: Ligand Binding Pocket; DBD: DNA Binding Domain.
Binding pocket signatures are more diverse in McyB1 A domains, reflecting the diversity of amino acid residues incorporated in position X (Table 6).
