Sentence examples for bound of the mutation from inspiring English sources
This strategy is apparently conservative and can be regarded as the lower bound of the mutation rate.
For example, it has been suggested that the lower bound of the mutation rate is set by the efficiency of selection for maintenance or improvement to DNA repair, which will be primarily limited by the effective population size [ 50].
For six of the seven fitness components for which there are ML estimates, the average lower bound of the mutation rate is 2.2 × 10−3 mutations per haploid genome per generation.
This suggests that we can compute a lower and upper bound of the mutation rate from (1), so that there is sufficient power (⩾80%) to detect a specific effect, Δ, if the mutation rate falls between the bounds.
Error threshold is the upper bound of the mutation rate such that the genetic information can pass on during reproduction.
Under the assumption of common ancestry of the sequences obtained from DCV isolates in our laboratory and the EB isolate deposited in GenBank 11 years ago [23], we estimated an upper bound of the mutation rate (i.e., the number of variable synonymous sites divided by the sequence length times divergence time).
This allows a lower bound on the mutation rate to be calculated by determining the mutation rate (in a Poisson process) at which the probability of obtaining zero no-mutation lines in 90 MA lines is less than 5%.
Using the lower bounds of the mutation rates for each fitness parameter, we can place a lower bound on the overall rate of mutations that alter some component of fitness in D. discoideum by summing them.
It appears that the correlation between the NC-p1 complex structure with the other natural substrate bound structures increases as a result of the mutation V82A in the protease.
Inability of the mutation Q165H to bind the cofactor indicates that regardless of the substrate, no enzymatic reaction requiring NADH or NAD+ (all known reactions) will be sufficiently catalysed by this mutant protein.
The mutation is located on a part of the protein that normally binds with the LDL receptor, and binding is reduced as a result of the mutation.
