In a structure of SyrB2 with bromide bound in place of chloride, the position of the bromide almost exactly overlays the location of the chloride, and no changes are observed in the surrounding protein structure.
In some crouched burials, however, there is reason for suspecting a more sinister motive; for the limbs are sometimes so tightly flexed that the bodies must have been bound in that position before rigor mortis set in.
Y1135 (being the first tyrosine to be phosphorylated after stimulation with ligand) in the a-loop is bound in cis position in the active site, thus preventing the substrate access and occluding the ATP binding site as well.
In 4,5-di-O-caffeoylquinic acid both caffeoyl arms are bound in equatorial position and this geometry forces the two aromatic plane in an orthogonal orientation with respect to the plane of the quinic saturated ring, in order to minimize steric clashes (see Fig. 4).
Electron density was clear for both the inhibitor PUGNAc and 2 bound in adjacent positions.
A minor, yet frequently found glycan moiety on human serum IgG is bisecting GlcNAc, i.e. GlcNAc bound in β1,4-position to the innermost mannose residue [9].
Coalter was bagged and locked in the box; Kuribayashi bound in a contorted position and stuffed in a latched duffelbag; Ahern and Del Rosario chained to each other and to a thirteen-foot pole; Kriston duct-taped to a chair, with a plastic bag secured over her head.
After OLA128 dissociated from the protein, the second ligand (OLA129) was still bound in an inner position of the protein cavity, which was distant from the "portal region".
The remaining AMP was bound in the same position as the single molecule observed in the yeast structures.
Structural comparisons are also valuable in assigning H2O/OH− as the ligand; recent ChCODH and MbCODH structures also contain H2O/OH− bound in the same position on Fe, a site that is unavailable in structures that contain the bridging sulfide.
