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Furthermore, the Cramer-Rao bound has been evaluated and compared with the RMSE results of the proposed algorithm.
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The monoclonal IgG1 antibody, Bevacizumab (Avastin), which binds VEGF preventing receptor binding, has been evaluated in the first- and second-line treatment in patients with colorectal cancer (Willett et al, 2004, 2006; Chua and Cunningham, 2006; Rasheed et al, 2008).
Ixabepilone - an epothilone B analog that increases polymerization but that, unlike the taxanes, has the capacity to bind to multiple isomers of tubulin - has been evaluated in the setting of patients pretreated with anthracyclines, taxanes, and capecitabine as well as in first-line metastatic treatment of patients treated with adjuvant anthracyclines.
Denosumab has been evaluated in three identically designed, randomised, double-bind, phase III clinical trials [5 7].
Corresponding error bound has been derived.
Only one SWAps has been evaluated independently.
The upper bound had been reached.
Binding constants with the strongly interacting metal ions have been evaluated from fluorescence titration data.
Binding affinities of the compounds to the transmembrane domain of mGluR5 have been evaluated using nitric oxide (NO) production assay, while the safety of the compounds is tested.
The mTOR inhibitor rapamycin and its analogs bind FK506 binding protein, and this complex binds to mTORC1, inhibiting downstream signaling [ 30 ]. Everolimus and temsirolimus are rapamycin derivatives that have been evaluated in the treatment NET (Tables 1 and 2 ).
But all the cases that have been evaluated have failed.
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