Sentence examples for bound growth from inspiring English sources
Like other membrane bound growth factors/proteins, the mkirre protein could be cleaved by metalloproteinase while releasing the extracellular domain which is responsible for supporting the HSC [ 12].
Hkirre protein is cleaved by proteolytic mechanism as observed in other membrane bound growth factors, receptors, or adhesion molecules, which is quite similar to SCF regulated by MMP9 [ 40].
The cleavage of the extracellular matrix (ECM) by activated MMPs facilitates the invasion of tumor cells as well as the release of ECM bound growth factors (e.g. of insulin like growth factors and fibroblast growth factors).
Bound growth factors provide an "on demand" depot and are protected from denaturation or proteolytic degradation, while their biological activity can be augmented when released by natural enzymatic means such as heparanase activity (Decarlo et al. 2012; Knox and Whitelock 2006; Mongiat et al. 2001; Takada et al. 2003; McKeehan et al. 1999; Farach-Carson et al. 2014; Whitelock et al. 1996).
Nevertheless, this approach still cannot avoid partial removal of ECM molecules, particularly the weakly bound growth factors.
It consists of neighboring cells, extracellular matrix (ECM) components and soluble and bound growth factors and cytokines that govern self-renewal and maturation/differentiation status [ 68].
This protein has no ligand-binding domain of its own and cannot, therefore, bind growth factors.
GAGs are known to specifically bind growth factors and modulate their activity.
EGFR may also bind growth factors secreted by the epithelial cells themselves in an autocrine loop [ 48], which has been demonstrated for amphiregulin in the case of HT-29 [ 49] as well as Caco-2 [ 50] cells.
Many of the heparan sulfate PGs are present on cell surfaces as receptors where they bind growth factors and orchestrate their delivery and signal transduction to the cell nucleus [ 41].
Assuming that all of the assimilated carbon that is not bound in growth is respired, approximately 4.3 times more carbon is used in respiration than in growth.
