MBL can also recognize and bind damaged host cells [18] and it is possible that this collectin might also recognize damaged cells in the central nervous system.
These oligomeric complexes which bind damaged crystallins, but do not refold them, may become saturated in later life.
During NHEJ, DNA-dependent protein kinase (DNA-PK) binds damaged DNA with high affinity and acts as the main scaffold for other repair factors.
In this role, PARP1 binds damaged DNA and this interaction stimulates auto-PARsylation of PARP1 and trans-PARsylation of additional DNA repair mediators such as XRCC1 and chromatin structure proteins such as histones.
LOX-1 has the ability to bind damaged or apoptotic cells, activated platelets, advanced glycation end products, and pathogenic organisms [ 144, 145] and so it may play a role in initiating and potentiating the early steps of atherogenesis.
The tide of brown water that is now polluting the sea off eastern Australia is bound to damage already damaged marine ecosystems.
Thus, GAPDH-bound damaged mitochondria are likely accumulated around the lysosomal structures and/or internalized into them without proper degradation because of impaired lysosomal function in cells by expanded polyglutamine repeats as mentioned above (Appendix Fig S3H).
Certainly, within the complex field of traumatic knee injuries, a distortion with damage to the lateral meniscus is bound to damage this ligamentous structure as well.
The Communist Party at first held that a strong administrative organization was bound to damage the revolution by dampening spontaneity and other revolutionary virtues.
Yet there is little sign those measures have had any effect, and Mr Putin's actions are bound to damage the wider Russian economy.
What I do feel moved to point out is that leaks are an asymmetrical form of warfare – like Apache helicopters or IEDs on the Afghan or Basra road – bound to damage the US and Britain more than it does their critics and enemies.
