Sentence examples for bound at the active from inspiring English sources

The ferrous ion bound at the active sites is essential for the activity of hydroxylases.

Specifically, the effect of KCl concentration on HDAC8 activity was investigated by Fierke and co-workers using HDAC8 with two different divalent metal ions (Co2+ and Zn2+) bound at the active site.[ 5] These experiments revealed a bell-shaped activity profile, with an activating effect at lower concentrations of K+ and an inactivating effect as the concentration was increased.

In general, SODs have a strict metal binding specificity for enzymatic activities with the exception of a class of enzymes which show enzymatic activity regardless of whether Fe or Mn is bound at the active site; these are known as cambialistic forms [ 2- 5].

First, adenine is bound at the active site in the crystal structures of GAP31 to HIV-LTR duplex DNA with 5′ overhanging adenosine ends, such as the 3′-processed HIV-LTR DNA but not to DNA duplex with blunt ends.

Indole is not oxidized by the wild-type enzyme; it lacks the carboxylate group by which the proper fatty acid substrates are supposed to be bound at the active site of the native enzyme, via hydrogen bonds to the charged amino acid residues Arg47 and Tyr51.

The comparison of the complexes of the antifolate inhibitor pyrimethamine bound at the active sites of PvDHFR and PfDHFR, the related enzyme from Plasmodium falciparum, prospected the possibility of using structure-based drug design to develop inhibitors that are effective against both malarial enzymes.

Through these interactions, the inhibitors bind at the active site so that the protease can be restricted to the closed configuration.

Two Mn2+ ions bind at the active site, inducing relocation of the scissile phosphodiester towards the active site (1.6-Å shift in the position of the P atom; Figure 3B).

UDP-N-acetylglucosamine and Mg2+ are bound at the uridyltransferase active site, which is in a closed form.

Specifically, we find ALKBH3 bound at active gene promoters, enhancers, and regions with putative quadruplex DNA.

The first synthetic MMP inhibitors bound tightly at the active site and therefore blocked enzyme activity.