Sentence examples for bound at different sites from inspiring English sources

In addition, different substrates bind in different regions of the large promiscuous binding site, so it is challenging to understand how drugs bound at different sites can communicate with the NBDs to stimulate ATP hydrolysis.

In the absence of suitable competitive binding assays, compound 1 was predicted to bind at the AMP allosteric site based on superposition onto known inhibitors which bind at different sites in the enzyme and analyses of the surrounding protein environment associated with these distinct sites.

RASSL design is based on the premise that endogenous peptide hormones bind at different sites on the cognate receptors than do small-molecule synthetic ligands.

Otherwise, if the interactors bind at different sites of their common partner, the interaction is considered simultaneously possible.

Our results here may suggest that these diverse protein partners bind at different sites on the domain surface.

Do FOXP3 IRF4 complexes bind at different sites to FOXP3 GATA3 complexes and do the different binding partners lead to different local histone modifications and associated changes in gene activity?

(14) In contrast, the lack of competition between thioflavin T (1) and propidium (2) with BuChE indicates that these inhibitors bind at different sites on this enzyme.

That both heparan sulfate and laminin can interact with 37LRP simultaneously suggest that the two molecules bind at different sites and that there is limited (or no) allosteric communication between these sites.

With BuChE, competition studies between thioflavin T (1) and edrophonium (3) (Table 1, Figure 4) suggest that these two inhibitors bind at different sites on this enzyme as well.

To test the idea that Cu II) and Zn II) bind at different sites, we monitored the effect of added Zn II) on the Cu II -induced oligomerization of β2m.

Some of miRNAs can bind at different sites within the 3′UTR of the target gene at different MFEs and different modes of binding as illustrated in the description of Figure 3.