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Further, it was shown that MeaB protects MCM from inactivation and that the state of MeaB (apo, GDP or GTP bound) alters the affinity of MCM for AdoCbl (Ref. 129).
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Members of both groups of HMG-box proteins also bind altered nucleic acid structures such as 4-way junctions [ 11- 13] and cisplatinated DNA [ 14].
It contributes to inflammation and atheromatogenesis by recruiting circulating monocytes that bind altered microvascular and arterial endothelium by triggering shear-resistant monocyte arrest [ 49].
A further intricacy occurs when the bound drug alters the rates of transition between ion-channel states.
It could be that structural differences caused by the aptamer sequence or bound ligand alters the stability of the aptamer-AS-2 RNA enough to account for these observed differences.
Since the jet stream, which is a corridor of strong winds at upper levels of the atmosphere that generally blows from west to east across the northern mid-latitudes, is powered by the temperature difference between the Arctic and areas farther south, any alteration of that temperature difference is bound to alter the jet stream — with potentially profound implications.
This may not become immediately obvious in 2015, but it is bound to alter the landscape by 2020.
ASK ABOUT CHANGES Emerging adults are bound to alter their appearance and habits, and you don't want to learn your daughter is a vegetarian as you slice the turkey.
The author's fresh, penetrating critique is bound to alter and deepen our understanding of the human dynamics as well as the theoretical imperatives that vitalized the Constructivist project.
The new question is whether English will consume other tongues or generate a multiplicity of dialects.Performing on an empty yet virtually teeming global stage is bound to alter how artists conceive their work, Ms Wood observes.
But officials in the State Department and Pentagon, as well as key lawmakers, said Bin Laden's death was bound to alter the debate about a costly war soon to enter its second decade.
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CEO of Professional Science Editing for Scientists @ prosciediting.com