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While the second K+ ion reached the lower binding site between the bottom and central G-tetrads through the bottom pathway, it bound at 159.3 ns and spent about 5.6 ns to accomplish the binding process.
Actions (top pathway) combine with language (bottom pathway) to generate a proof with intuition, which is hypothesized to be mediated by simulated action, as exhibited by the speaker's dynamic gestures and transformational speech.
The variations in sim-K1 corresponding to the top and bottom pathway binding processes were respectively colored black and green, the variations in sim-K2 corresponding to the top pathway binding processes were colored purple.
In addition, we found that dehydration consistently started from the lateral coordinated waters of K+ by checking the interval conformations, and the traversing process started with the bottom coordinated water of K+ through the top pathway, or the top water through bottom pathway.
While the top area became increased by about 0.04 nm2 due to the upward shift of the first K+ ion pushed by electrostatic repulsion from the second K+ ion, the bottom G-tetrad gate area decreased significantly by the binding of the second K+ ion through bottom pathway.
Unlike chlorophenols, chlorobenzenes, have a propensity to undergo a bidentate adsorption, which results in bottom pathway in Figure 5 (Through bidentate species).
Similar(51)
Upon hyperosmotic shock (bottom ), pathways coupled to the Sho1 and Sln1 osmosensors lead to Hog1 activation.
Chitin microspheres with well-defined nanofibrils were fabricated through a "bottom up" pathway.
The E. coli harboring the bottom MVA pathway of S. pneumoniae produced the highest amount of β-carotene.
In fact, these terms define the bottom-up pathway.
It reflects the necessity that the matching in the bottom-up pathway needs to be consistent with the matching in the top-down pathway to ensure an overall consistent behaviour.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com