Ranking of the most stably expressed genes from top to bottom and determination of the optimal number of genes needed for normalisation.
The notion of a moral consideration's "strength," whether put forward as part of a metaphysical picture of how first-order considerations interact in fact or as a suggestion about how to go about resolving a moral conflict, should not be confused with the bottom-line determination of whether one consideration, and specifically one duty, overrides another.
But rather than frustration, Vestager exudes quiet and determined determination to get to the bottom of the tax riddles.
BmDSXF is a functional switch at the bottom of sex determination pathway in the silkworm [ 12, 13].
An important problem in the study of microparticles in the marine environment, suspended in the water column or deposited as sediment on the ocean bottom, is the determination of provenance of the microparticles where did they come from and by what processes were they transported to the sampling location?
The gene doublesex (dsx) is at the bottom of the sex determination genetic cascade and is transcribed in both sexes, but gives rise to two different proteins, DsxF and DsxM, which impose female and male sexual development respectively via the sex-specific regulation of the so-called sexual cyto-differentiation genes.
Like the principle of compositionality, (Fall) can be interpreted as a claim about reference or meaning, locally or globally, collectively or distributively, in a language-bound manner or cross-linguistically. Compositionality is about bottom-up meaning-determination, while the context principle about top-down meaning-determination.
In the model system Drosophila melanogaster, doublesex (dsx) is the double-switch gene at the bottom of the somatic sex determination cascade that determines the differentiation of sexually dimorphic traits.
Dsx and Fru are the only identified factors at the bottom of the sex-determination hierarchy, and both of these transcriptional regulators act in the same neurons to bring about male-specific neuronal wiring and male-specific behavioral patterns [ 45 47].
In the present study, to gain insight into the mechanism of male killing by Wolbachia, we focused on a gene working at the bottom of the sex-determination cascade, doublesex (dsx), which is transcribed into either a male or female isoform by sex-specific splicing and serves as a final regulator of sex-specific gene expression in somatic cells of insects [ 10, 11].
Both dsx and fru lie at the bottom of the sex-determination hierarchy and in males act in concert to specify sex-specific neural circuitry and physiology [ 2]. fru is a pleiotropic gene with at least two major functions, one that controls male sexual behavior and another that is essential for viability in both sexes [ 1].
