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Second, we will discuss the importance of bottlenecks, which are important stochastic non-recurrent events promoted by climatic, geographic, and other environmental changes that probably reduced genetic and phenotypic variations in the populations during their dispersal across the continent.
However, the bottlenecks adopted by the existed scheduling strategies are often partial bottlenecks, local bottlenecks, or even deceptive bottlenecks, which are basically not key constraints to achieve optimal objective, so that the corresponding scheduling strategies are not perfect, and the further improvement and evaluation can hardly be proposed.
We need to find out why and remove the bottlenecks which are preventing scale-up".
This method has bottlenecks, which are the huge candidate sets and multiple scans of the entire database with high computational costs.
One possibility is that these boom-bust cycles are the equivalent of annual population bottlenecks, which are expected to result in reduced genetic diversity and random changes in allele frequencies over time due to the genetic drift inherent in small populations [30] [32].
In any case, we should keep in mind that the results of this test must be taken with extreme caution, being strongly affected by population bottlenecks, which are known to affect the reliability of it [ 29].
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The ambassador added that officials were trying to ensure the comfort of evacuees and to avoid bottlenecks, which was one reason for doing it in stages.
But both of these processes have to be rescheduled at intervals longer than the internal processing time they require, to avoid bottlenecks, which is why parameter 5 has been set to the upper limit of the action selection duration described in the Results section.
Allele frequency distribution (mode shift indicator) was used to illustrate the bottlenecks which were tested simultaneously by the Wilcoxon test [ 19].
Also, each node keeps "close bottlenecks", which is a set of bottleneck nodes of which distance from the nodes ≤ 2. Each node in the starting node set forms an initial cluster.
The analysis here hints at low effective population sizes – perhaps the immune system induces a heavy decline in population sizes of M. tuberculosis within patients, i.e., bottlenecks – which is overcome by survivors with new genotypes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com