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Even though metabolic engineering has taken long strides in manipulating the metabolic network towards the overproduction of a desired chemical, the process is hampered by bottlenecks of time and accuracy.
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In appropriate applications and with specialized computing architectures they might even circumvent the bottleneck of time-consuming memory access, as computation is inherently performed with non-volatile computing states.
The primary bottleneck of reverse time migration is applying the finite-different stencil.
The rate-limiting section of the conceptual process was analyzed using discrete-event system simulation to determine expected production rates, bottlenecks, and the effects of time delays on the production rate.
Multiple extinction and recolonisation events possibly caused by a higher rate of tectonic rearrangements and eruptive phases in the southern EPR [ 75, 76], would have favoured the recurrence of bottlenecks through time as previously seen from the long-term monitoring of targeted vent fields since 1991 [ 77, 78].
We now define the memory of the system, (vec R^{N}(t)=({R^{N}_{c}}(t), {R^{N}_{p}}(t))), that consists of a pair of real numbers that represents the normalised population of packets enqueued at the bottleneck at the end of time slot t and t−1, respectively.
The four parameters involved are the constant ancestral population size N1, the bottleneck
Park and Shi [2] suggest strategies of deploying additional sensors in the bottleneck zone in due course of time to maintain a desired level of network connectivity.
Specifically, causing population bottlenecks within invasive species, especially if the bottleneck is sustained for a period of time, and is in response to an unrelated selective agent such as herbicide, could greatly affect the ability of invasive species evolve to better compete with co-occurring native populations.
Lack of time was a bottleneck for increasing physical activity (intervention: 17%; usual care: 23%).
However, without DNA resource limitations, a genotyping bottleneck exists mostly as a result of time- and assay set-up costs and hence, in order to achieve large-scale genotyping, highly multiplexed assays are required.
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