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Understanding the physiology of the BBB and the mechanism of permeation across the BBB is critical in overcoming this bottleneck in development and in designing effective and safe treatments for the rising number of patients suffering from neurological diseases and cancers.
It also means a potential bottleneck in development time as game companies work to add another control scheme into their games.
The bottleneck in development of tissue engineering scaffolds often lies on the formation of vascular networks through angiogenesis and vasculougenesis.
Tissues of an individual may display LH to various extents [16], especially when they go through a tight bottleneck in development, such as observed in mitochondria of hair shafts.
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The effort will require an international commission to avoid duplication of effort and identify bottlenecks in development, the authors note.
Since these processes are often a bottleneck in the development of the FCEV, we hope that the present review will be helpful to the development and improvement of the technology related to FCEVs.
However, incomplete dehydrogenation has been a bottleneck in the development, as the dehydrogenation catalysts do not have satisfactory catalytic properties.
Transforming narrative guidelines into a computer-interpretable formalism is still a bottleneck in the development of decision-support systems.
The catalytic mixture operated under mild conditions and rapidly depolymerized cellulose the main bottleneck in the development of a commercial process for the conversion of cellulosic biomass.
Ultimately, all effective compounds must be tried in animal models and subsequently in man and these two stages remain the bottleneck in drug development.
However, the major bottleneck in the development of drug delivery systems that match the circadian rhythm (chronopharmaceutical drug delivery systems: ChrDDS) may be the availability of appropriate technology.
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