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Jeanne Schabarum makes a joke to get through a bothersome activity: building gingerbread houses with graham crackers, jelly beans, Skittles and pink and white frosting.
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If a symptom was present, patients rated the severity of the symptom on a scale of 1 (mild, symptoms did not interfere with usual activities), 2 (moderate, symptoms interfered somewhat with usual activities) or 3 (severe, symptoms were so bothersome that usual activities could not be performed).
Symptoms of breathlessness and cough are extremely bothersome and limit physical activity, social participation, travel, and sexual relations.
We sought to examine the utility of the daily pill-taking process itself, viewing aspects such as bothersome side effects, activity limitations, and any required therapeutic monitoring as separate issues, which would vary from pill to pill.
The CGI of disease symptoms was determined by investigators by asking patients to rate symptoms at each visit as none (absent), mild (present, but not bothersome), moderate (bothersome), severe (interfered with normal activity), or incapacitating (prevented normal activity).
Betsy McCaughey Ross's bothersome?
"It's not bothersome.
That is seriously bothersome.
Ms. Eaglen's slight flaws were bothersome.
"That is somewhat bothersome," he added.
I must confess they did not prove too bothersome there".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com